![]() ![]() Phytochemical screening was done with liquid chromatography-mass spectrometry LC- (MS)/MS and direct analysis in real time-MS to detect active compounds in the fractions. ![]() Further, we did fractionation of this CMFE into two fractions namely CMA water fraction (CMWF) and CMA hexane fraction (CMHF). Materials and Methods: For initial anti-dyslipidemic and antihyperglycemic potential of CMA fruit extract (CMFE), male Syrian golden hamsters were fed a chow or high-fat diet with or without CMFE (100 mg/kg). This study aimed to explore anti-dyslipidemic and anti-adipogenic potential of CMA. Gaikwad, Anil N.īackground: Cucumis melo ssp. Kumar, Durgesh Varshney, Salil Gupta, Abhishek Rajan, Sujith Srivastava, Ankita Beg, Muheeb Srivastava, Anurag Kumar Kanojiya, Sanjeev Mishra, Dipak K. Agrestis Ameliorates High Fat Diet Induced Dyslipidemia in Syrian Golden Hamsters and Inhibits Adipogenesis in 3T3-L1 Adipocytes agrestis, CMFE: CMA fruit extract, CMWF: CMA water fraction, CMHF: CMA hexane fraction, FAS: Fatty acidĬucumis melo ssp. Abbreviation used: CMA: Cucumis melo ssp. The oral administration of Cucumis melo agrestis fruit extract (CMFE) and its fractions (CMWF and CMHF) improved serum lipid profile in HFD fed dyslipidemic hamsters.CMFE, CMWF and CMHF significantly attenuated body weight gain and eWAT hypertrophy.The CMHF decreased lipogenesis in both liver and adipose tissue.CMFE and CMHF also inhibited adipogenesis in 3T3-L1 adipocytes. Based on these results, it is concluded that CMA possesses anti-dyslipidemic and anti-hyperglycemic activity along with the anti-adipogenic activity. CMFE and CMHF also decreased oil-red-O accumulation in 3T3-L1 adipocytes. Standard biochemical diagnostic tests suggested that neither of fractions causes any toxicity to hamster liver or kidneys. CMHF also modulated expression of genes involved in lipogenesis, lipid metabolism, and reverse cholesterol transport. Oral administration of CMFE and both fractions (CMWF and CMHF) reduced the total cholesterol, triglycerides, low-density lipoprotein cholesterol, and very low-density lipoprotein-cholesterol levels in high fat diet-fed dyslipidemic hamsters. Further, high-fat diet fed dyslipidemic hamsters were treated with CMWF and CMHF at 50 mg/kg for 7 days. For initial anti-dyslipidemic and antihyperglycemic potential of CMA fruit extract (CMFE), male Syrian golden hamsters were fed a chow or high-fat diet with or without CMFE (100 mg/kg). Shankar, Kripa Singh, Sumit K Kumar, Durgesh Varshney, Salil Gupta, Abhishek Rajan, Sujith Srivastava, Ankita Beg, Muheeb Srivastava, Anurag Kumar Kanojiya, Sanjeev Mishra, Dipak K Gaikwad, Anil NĬucumis melo ssp. Agrestis Ameliorates High Fat Diet Induced Dyslipidemia in Syrian Golden Hamsters and Inhibits Adipogenesis in 3T3-L1 Adipocytes. It provides an overview of this virus reservoir for growers, extension workers, crop consultants and research and regulatory scientists.Ĭucumis melo ssp. This is the first report of Papaya ringspot virus type W infecting Cucumis melo var. USDA-ARS?s Scientific Manuscript database Detection of Papaya ringspot virus type W infecting the cucurbit weed Cucumis melo var.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |